Increased Functional Stability and Homogeneity of Viral Envelope Spikes through Directed Evolution

... in the development of Env immunogens that stably retain native, trimeric structure. A vaccine is needed to prevent HIV/AIDS but eliciting potent neutralizing antibodies (Abs) against primary isolates has been a major stumbling block. The target of ...

http://www.citeulike.org/user/memerman/article/12721392