Characterization of human IgG repertoires in an acute HIV-1 infection

Experimental and Molecular Pathology , Vol. 93, No. 3. , pp. 399-407, doi:10.1016/j.yexmp.2012.09.022 All known broadly neutralizing antibodies are highly somatically mutated and therefore significantly differ from their germline predecessors.

http://www.citeulike.org/user/MyPhD/article/11408206