The SAMHD1 knockout mouse model: in vivo veritas?

SAMHD1, a dNTP hydrolase mutated in the autoimmune encephalopathy Aicardi-Goutières syndrome, restricts HIV replication in non-dividing human cells by reducing intracellular deoxyribonucleotide pools.

http://www.nature.com/emboj/journal/vaop/ncurrent/full/emboj2013190a.html